Photocatalytic Degradation of Allopurinol using Cerium Oxide

Authors

  • K. Sridevi Lakshmi PG Student, Department of Environmental Engineering, Government College of Technology, Coimbatore, Tamil Nadu, India
  • J. Jeyanthi Associate Professor, Department of Civil Engineering, Government College of Technology, Coimbatore, Tamil Nadu, India
  • R. Bhuvaneswari Assistant Professor, Department of Civil Engineering, Government College of Technology, Coimbatore, Tamil Nadu, India

DOI:

https://doi.org/10.51983/tarce-2018.7.2.2259

Keywords:

Allopurinol, Cerium oxide, Characterization, Photocatalysis

Abstract

Allopurinol (AP) is an antigout drug under the brand names Zyloprim and Zyloric. It is a structural isomer of hypoxanthine, a naturally occurring purine in the body which inhibits xanthine oxidase that results in decrease in uric acid formation. In this work, degradation of aqueous solution of Allopurinol by photocatalysis was studied using CeO2. The CeO2 was synthesized by Co-Precipitation method and it was characterized by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM/EDAX), FTIR and BET Surface Area Analyzer. FTIR confirms the finger print region for CeO2around 829.92cm-1. Surface area of CeO2 was measured as 64.42m2g-1 by BET surface area analysis. The optical and thermal stability was determined using DRS UV-Visible spectroscopy and Thermo gravimetric analysis. In this study the concentrations of Allopurinol was quantified using UV-Visible Spectroscopy. The feasibility of photo degradation of allopurinol using CeO2 was carried out in the presence of UV irradiation of 254 nm. The optimization of process control parameters such as catalyst dosage, pH and allopurinol concentration was assessed. From the assessment, degradation rate decreases with increase in initial concentration of Allopurinol whereas it increases with increase in CeO2 concentration up to 0.04g/l. In case of pH, degradation constant increases with increase in pH from 8.5 to 11.

References

Khayoon, et al., “Spectrophotometric Determination of Allopurinol in Tablet Formulation”, Journal of Physical Science, Vol. 19, No. 2, pp. 23-30, 2008.

Srujani. Ch., et al., “UV spectroscopic method development and validation of allopurinol in bulk and pharmaceutical dosage form”, World Journal of Pharmaceutical Research, Vol. 3, No. 9, pp. 1404-1413, 2014.

Farzadkia et al., “Photocatalytic degradation of Metrodinazole with illuminated TiO2 nanoparticles”, Journal of Environmental Health Science & Engineering, Vol. 13, No. 35, DOI 10.1186/s40201-015-0194-y, 2015.

Hoffmann., et al., “Environmental applications of semiconductor photocatalysis”, Vol. 95, No. 1, pp. 69-96, 1995.

YongqingZhai., et al., “Preparation, Characterisation and Photocatalytic activity of CeO2 nano crystalline using ammonium bicarbonate as precipitant”, Materials Letters, Vol. 61, pp. 1863–1866, 2007.

Jazmin Calvache-Munoz, et al., “Cerium Oxide Nanoparticles: Synthesis, Characterization and Tentative Mechanism of Particle Formation”, in Colloids and Surfaces A: Physicochemical and Engineering Aspects, [Online]. Available: http://dx.doi.org/10.10 16/j.colsurfa.2017.05.059

S. Sarkar, et al., “Photocatalytic degradation of pharmaceutical wastes by alginate supported TiO2 nanoparticles in packed bed photo reactor”, Ecotoxicology and Environmental Safety, 2015. [Online].

Available: http://dx.doi.org/10.1016/j.ecoenv.2015.02.035i,

Devadoss, et al., “Structural, Optical, Morphological and Dielectric Properties of Cerium Oxide Nanoparticles”, Materials Ressearch, Vol. 19, No. 2, 2016. [Online]. Available: http://dx.doi.org/10.1 590/1980-5373-MR-2015-0698.

E. K. Goharshadi, et al., “Fabrication of cerium oxide nanoparticles: Characterisation and optical properties”, Journal of Colloid and Interface Science, Vol. 356, pp. 473-480, 2011.

B. Rajkumar, et al., “Reverse phase HPLC method development and validation for the simultaneous quantitative estimation of alpha lipoic acid and allopurinol in tablets”, International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, No. 1, pp. 307-312, 2014.

C. Benmouhoub, et al., “Synthesis and characterization of Cerium oxide (CeO2) nanoparticles”, Materials Science Forum, Vol. 609, pp. 189-194, 2009.

Liming yang, et al., “Degradation of paracetamol in aqueous solution by TiO2 photocatalysis”, Water research, Vol. 42, pp. 3480-3488, 2008.

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Published

05-11-2018

How to Cite

Sridevi Lakshmi, K., Jeyanthi, J., & R. Bhuvaneswari. (2018). Photocatalytic Degradation of Allopurinol using Cerium Oxide. The Asian Review of Civil Engineering, 7(2), 39–44. https://doi.org/10.51983/tarce-2018.7.2.2259